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Now, to pull this all together when we do not have enough circulating folate, our bodies cannot create sufficient levels of glutathione

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228,229,230 Inhibiting xCT The search for strategies and drugs aimed at inducing oxidative stress has revealed xCT to be a suitable targetincreased glutamate efflux through this antiporter is an important process for cells to generate sufficient glutathione to cope with high intracellular ROS levels